Experimental Study and Modeling of Solid-liquid Equilibrium for Binary and Ternary Pharmaceutical and Food Systems

Background: The experimental measurement of the solubility a solute in given solvent is difficult task; hence, there need for reliable thermodynamic models its prediction. However, these require either molecular or group interaction parameters, which are not always available. Objective: objective present study to measure experimentally different solutes solvents selected from pharmaceutical food fields on basis that all required model parameters available use obtained data their determination. Methods: solid-liquid equilibrium chosen binary and ternary systems at temperatures was carried out using differential scanning calorimetry determine essential thermophysical properties like melting temperature enthalpy. modeling phase performed Random Two Liquids (NRTL) Universal Functional Activity Coefficient (UNIFAC). NRTL were determined by minimizing well-defined function simplex method. Results: solubilities considered provided parameters. Solute NRTL, UNIFAC, ideal models. comparisons showed an excellent agreement between values results, contrary UNIFAC case Conclusion: This shows importance predict may be difficult, time-consuming, costly obtain experimentally.